Upstream Bio, Inc.
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Price history
Chart
Interactive price chart (TradingView).
52-week range: 5.30 $ to 32.60 $ · Last price: 5.30 $ (As of: September 17, 2026)
Key figures
Key figures at a glance
Every figure we hold for this stock, grouped by topic. The question mark next to a label explains what the number means.
Basics
Performance
Technical Indicators
Calculated from the price history · as of 09/18/2026
Valuation
Profitability
Balance Sheet & Safety
Growth
Dividend
This stock currently pays no dividend.
Quality & Screener
Highlighted are things our editorial team noticed: green = stands out as strong, red = deserves a closer look. No single metric is a verdict on its own — always read it in context.
Comparison
Industry comparison
The stock alongside the largest companies in the same group. The median row is the middle value of the companies shown above — not of the whole industry.
Industry: Biotechnology
| Company | Market cap ($B) | P/E | EV/EBITDA | Gross Margin % | EBIT Margin % | Sales Growth (Year) % | Perf. 1Y % |
|---|---|---|---|---|---|---|---|
| Upstream Bio, Inc. UPB | 0.3 | – | 0.0 | 100.0 | – | 20.4 | -66.9 |
| Vertex Pharmaceuticals Inc VRTX | 130.6 | 31.3 | 24.5 | 55.0 | 38.1 | 9.6 | 33.4 |
| Regeneron Pharmaceuticals Inc REGN | 82.0 | 19.9 | 13.1 | 44.5 | 20.7 | 1.0 | 35.5 |
| Moderna Inc MRNA | 62.7 | – | 4.6 | -66.0 | -131.1 | -39.2 | 532.3 |
| argenx NV ARGX | 61.9 | 38.1 | 34.2 | 59.1 | 32.0 | 89.6 | 30.9 |
| Revolution Medicines Inc RVMD | 40.9 | – | -9.7 | -174,708.6 | 0.0 | -100.0 | 338.3 |
| BeiGene, Ltd. ONC | 40.0 | 63.1 | 34.1 | 88.9 | 19.1 | 40.2 | 6.4 |
| Alnylam Pharmaceuticals Inc ALNY | 32.6 | 61.8 | 28.4 | 79.7 | 23.0 | 65.2 | -48.1 |
| Royalty Pharma Plc RPRX | 32.5 | 31.8 | 19.6 | 95.8 | 100.3 | 5.1 | 68.6 |
| Median of companies shown | 40.9 | 34.9 | 19.6 | 59.1 | 21.8 | 9.6 | 33.4 |
Based on the most recently reported figures. Only stocks from the same trading venue are lined up, so the market caps are counted in one currency. Compare in a chart →
Fiscal years
Annual Figures
Fiscal years from the audited annual reports, oldest first. EBIT is the operating profit before interest and taxes; total assets are everything the company owns.
Revenue, operating income and net income per fiscal year $M
Revenue Operating income Net income
| Fiscal Year | Revenue ($M) | EBIT ($M) | Net Income ($M) | EPS ($) | Operating Cash Flow ($M) | Equity ($M) | Total Assets ($M) |
|---|---|---|---|---|---|---|---|
| 2022 | 1 | -24 | -24 | -0.66 | -19 | -106 | 18 |
| 2023 | 2 | -40 | -21 | -0.57 | -38 | -123 | 117 |
| 2024 | 2 | -78 | -63 | -1.22 | -59 | 470 | 482 |
| 2025 | 3 | -160 | -143 | -2.66 | -133 | 340 | 354 |
Quarters
Quarterly Figures
Each bar is one quarter, the last one is the most recent. Use the switch to step through the individual figures.
Revenue & Profit
Cash Flow
Balance Sheet
Margins
Per Share
Click the chart or tab into it, then use ← and → to step through the periods.
None of the selected stocks reports this metric. Pick another metric or switch between annual and quarterly.
· Total · per year
These companies report in different currencies — switch on “Indexed” or pick a margin for a fair comparison.
The figures could not be loaded right now.
Source: fundamental data
| Quarter | EPS (Earnings Per Share) | EPS YoY (%) | Sales ($M) | Sales YoY (%) | Net Margin (%) | OCF ($M) | FCF ($M) |
|---|---|---|---|---|---|---|---|
| 2024: Q4 | -0.41 | – | 1 | 36.20 | -3,465.30 | -20 | -20 |
| 2025: Q1 | -0.51 | – | 1 | -11.60 | -4,818.00 | -41 | -41 |
| 2025: Q2 | -0.74 | – | 1 | 83.70 | -4,265.30 | -39 | -39 |
| 2025: Q3 | -0.63 | – | 1 | 12.50 | -4,941.10 | -22 | -22 |
| 2025: Q4 | -0.78 | – | 1 | 9.00 | -6,356.10 | -31 | -31 |
| 2026: Q1 | -0.75 | – | 1 | 82.70 | -3,925.60 | -48 | -48 |
| 2026: Q2 | -0.73 | 1.40 | 1 | -11.10 | -4,962.50 | -36 | -36 |
What Do These Terms Mean?
- EPS (Earnings Per Share):
- Quarterly profit divided by the total share count — how much of the profit works out to a single share.
- YoY (Year over Year):
- Change versus the same quarter a year ago — this is how you compare without seasonal distortion (e.g. the holiday shopping season).
- Sales:
- All revenue for the quarter, before any costs are deducted — the top line of the income statement.
- Net Margin:
- What percentage of sales is left over as profit in the end. Negative means the company is posting a loss.
- OCF (Operating Cash Flow):
- The cash that actually flows into the till from the core business during the quarter — harder to dress up than book profit.
- FCF (Free Cash Flow):
- Operating cash flow minus capital expenditures — the money that's genuinely free to use, say for paying down debt, buybacks, or dividends.
Screening
Appears in These Scanners
This stock currently matches 10 of our scanner strategies — each hit links to the scanner.
Quality & Balance Sheet
Momentum & Trend
Risk & Weakness
- Below the 50- & 200-SMA
- Downward Momentum
- Near 52-Week Low
- RS Weakness (≤10)
- Stage 4 (Downtrend)
- Stan Weinstein: Stage 4
- Stan Weinstein: Stage 4B-
- Weakness Cluster
Only genuine hits from verified scanners count; pure ranking metrics (P/E, P/S, and similar, which just sort the whole universe) don't count as a hit. Scanners marked in red are red-flag signals (risk/short scanners) — appearing there is not a seal of approval. View all scanners
Outlook
Analysts & Price Target
Combined picture of the price targets and recommendations of every analyst covering the stock. Price targets are expectations for the next 12 months, not promises — and they often follow the price rather than predict it.
Distribution of Recommendations
Estimates by Fiscal Year
| Fiscal Year | EPS Estimate ($) | EPS Range ($) | Revenue Estimate ($M) | Expected Growth | Analysts |
|---|---|---|---|---|---|
| 12/31/2026 | -2.90 | -3.26 – -2.17 | 3 | -9.2% | 8 |
| 12/31/2027 | -2.80 | -3.46 – -1.77 | 1 | 3.5% | 7 |
Average of the analyst estimates for the coming fiscal years. The range shows how far the most optimistic and the most cautious estimate sit apart — the wider it is, the less certain the expectation.
Valuation
What is priced in?
Free cash flow over the past twelve months is negative, which rules out a serious reverse calculation. Any growth rate only makes a negative cash flow more negative; no present value comes out of it. What the price reflects here is therefore not a stream of cash flows, but the expectation that there will be one at all.
A simplified model calculation — not a forecast and not a recommendation.
AI classification
AI Rating
Not yet rated — we only show a category once an SEC-backed file with at least two cited passages is available.
Growth
Growth Score
Ten checks against the annual reports — each one passed counts a point.
- Revenue grows by more than 15% a year over three years 33.0%
- More than 10% revenue growth is expected for the coming year -19.0%
- Share count grows by less than 3% a year 14.0%
- Revenue growth plus cash-flow margin add up to at least 40 ("Rule of 40") -4,655.1%
- Gross margin at 40% or higher and without meaningful erosion 100.0%
- Goodwill from acquisitions does not grow faster than revenue 0.0%
- Net debt below twice EBITDA 340 m net cash
- Operating cash flow covers the profits of the last three years -4 m
- Return on capital at 15% or higher, or up versus two years ago -47.1%
- Insiders hold at least 10% or are net buyers 14.9%
A criterion without figures counts neither as passed nor as failed; a score is only produced from 7 judgeable criteria upwards. Source: fundamental data. All ten criteria in detail
Quality check
AAQS
1/10The AAQS (AlleAktien Quality Score) checks 10 quality criteria on growth, profitability, and balance-sheet strength — per the methodology developed and published by AlleAktien, calculated by us from our own fundamental data. A stock counts as a quality stock from 9 out of 10 points. Where a company has a shorter listing history, we calculate over the fiscal years available (at least five).
- Sales growth 10Y > 5% –
- Exp. sales growth 3Y > 5% -29.9%
- EBIT growth 10Y > 5% –
- Exp. EBIT growth 3Y > 5% -29.9%
- Net debt < 4x EBIT –
- EBIT positive, 10Y straight –
- Max. EBIT decline < 50% –
- Return on equity > 15% -42.2%
- ROCE > 15% -47.1%
- Expected return > 10% -61.9%
View stocks with the full AAQS score · Read the methodology at AlleAktien
Source: fundamental data
The company
About the Company
Upstream Bio, Inc., ein Biotechnologieunternehmen in der klinischen Phase, entwickelt Behandlungen für entzündliche Erkrankungen mit Schwerpunkt auf schweren Atemwegserkrankungen.
- Employees
- 75
- Headquarters
- Waltham, MA
- Address
- 890 Winter Street, 02451 Waltham, United States
- Phone
- 781 208 2466
- Website
- upstreambio.com
- IPO Date
- 10/11/2024
- ISIN
- US91678A1079
Management
| Name | Title | Birth Year |
|---|---|---|
| E. Rand Sutherland M.D., M.P.H. | CEO & Director | 1970 |
| Michael Paul Gray CPA, MBA | CFO & COO | 1971 |
| Aaron Deykin M.D. | Chief Medical Officer and Head of Research & Development | 1967 |
| Stacy Price M.S., P.M.P. | Chief Technology Officer | 1969 |
| Meggan Buckwell | Director of Corporate Communications & Investor Relations | – |
| Allison C. Ambrose J.D. | Senior VP, General Counsel & Secretary | 1985 |
| Lisa Fiering | Senior Vice President of People & Culture | – |
| Adam Houghton M.B.A., Ph.D. | Chief Business Officer | 1971 |
| Mersedeh Miraliakbari Pharm.D. | Senior Vice President of Regulatory Affairs & Quality | – |
| Fang Xie Ph.D. | VP & Head of Biometrics | – |
Executives per the latest required filings; titles kept in their original language. Source: fundamental data.
Filings
Company Filings (8-K)
An 8-K is the filing a US company must use to disclose material events immediately — takeovers, changes at the top, major contracts or payment troubles, for instance. The links open the original document at the US Securities and Exchange Commission (SEC).
Data as of: September 17, 2026 · Source: fundamental data & SEC filings (annual and quarterly reports, 10-K/10-Q)
Note: pure fact-based analysis, not investment advice and not a solicitation to buy or sell. All figures without guarantee.