SYRE
Spyre Therapeutics Inc.
96.60$
-2.4%
vs. previous close
Closing price · As of: Oct 30, 2026
Ownership
Ownership Structure
Who owns Spyre Therapeutics Inc. (SYRE)? This page shows the largest institutions and funds, the ownership structure and the latest insider transactions. 88.3% of the shares are freely tradable; institutional investors hold 93.2%.
Institutional ownership
?Share of the stock held by institutional investors (funds, banks, insurers) according to regulatory filings.
93.2%
Insiders
?Share of the stock held by the executives, founders and major shareholders of the company itself.
5.9%
Float
?Share of stock freely tradable on the market — not locked up in the hands of founders, insiders, or major shareholders.
88.3%
Short % of float
?Shares sold short as a percentage of the freely tradable float — high values signal many bets on falling prices.
15.4%
Shares Outstanding
?Total number of shares issued. Price times share count gives market cap.
94Mio.
Largest Shareholders
Institutions
| Name | Stake (%) | Shares | Change (%) | Date |
|---|---|---|---|---|
| FMR Inc | 14.58 | 13,026,187 | +10.6 | 06/30/2026 |
| BlackRock Inc | 7.28 | 6,506,605 | +17.8 | 06/30/2026 |
| Perceptive Advisors LLC | 4.84 | 4,319,496 | +14.2 | 06/30/2026 |
| RTW INVESTMENTS, LLC | 4.76 | 4,251,996 | +1.9 | 06/30/2026 |
| Paradigm Biocapital Advisors LP | 4.30 | 3,840,778 | +96.2 | 06/30/2026 |
| Vanguard Capital Management, LLC | 3.86 | 3,448,681 | +12.8 | 06/30/2026 |
| State Street Corp | 3.42 | 3,057,416 | +17.3 | 06/30/2026 |
| VR Adviser, LLC | 3.34 | 2,985,448 | -19.0 | 06/30/2026 |
| T. Rowe Price Associates, Inc. | 3.31 | 2,960,855 | +85.2 | 06/30/2026 |
| Driehaus Capital Management LLC | 3.13 | 2,799,166 | +0.3 | 06/30/2026 |
Largest reported positions according to regulatory filings; stake as a percentage of shares outstanding, change versus the previous filing. Source: fundamentals data.
Insider holdings
| Person | Role | Shares | Value | As of | Type |
|---|---|---|---|---|---|
| Turtle Cameron | Chief Executive Officer | 537,540 | 51,926,364 $ | Oct 1, 2026 | direct |
| Burrows Scott L | Chief Financial Officer | 79,762 | 7,705,009 $ | Oct 1, 2026 | direct |
| Albers Jeffrey W. | Director | 9,360 | 904,176 $ | Aug 7, 2026 | both |
| King-Jones Heidy | See Remarks | 2,845 | 274,827 $ | Oct 1, 2026 | direct |
Holdings as of each person's most recent SEC Form 4 filing — excluding options and RSUs, which are not shares yet. Holdings may have changed between two filings.
Insiders
Insider Transactions
| Date | Person | Role | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Oct 1, 2026 | King-Jones Heidy | See Remarks | Sell | 2,600 | 93.46 | 242,996 |
| Oct 1, 2026 | King-Jones Heidy | See Remarks | Sell | 2,100 | 92.70 | 194,670 |
| Oct 1, 2026 | King-Jones Heidy | See Remarks | Sell | 7,228 | 91.35 | 660,278 |
| Oct 1, 2026 | King-Jones Heidy | See Remarks | Sell | 16,605 | 90.35 | 1,500,262 |
| Oct 1, 2026 | King-Jones Heidy | See Remarks | Sell | 400 | 89.24 | 35,696 |
| Oct 1, 2026 | King-Jones Heidy | See Remarks | Other | 28,933 | 14.50 | 419,529 |
| Oct 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 100 | 93.91 | 9,391 |
| Oct 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 4,990 | 93.37 | 465,916 |
| Oct 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 3,989 | 92.31 | 368,225 |
| Oct 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 2,638 | 91.49 | 241,351 |
| Oct 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 2,683 | 90.10 | 241,738 |
| Oct 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 600 | 89.14 | 53,484 |
| Oct 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 229 | 93.57 | 21,428 |
| Oct 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 3,071 | 92.95 | 285,449 |
| Oct 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 2,100 | 91.92 | 193,032 |
| Oct 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 1,500 | 90.27 | 135,405 |
| Oct 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 600 | 89.07 | 53,442 |
| Oct 1, 2026 | Burrows Scott L | Chief Financial Officer | Other | 7,500 | 14.50 | 108,750 |
| Sep 30, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 17,500 | 89.89 | 1,573,075 |
| Sep 30, 2026 | Burrows Scott L | Chief Financial Officer | Other | 17,500 | 14.50 | 253,750 |
| Sep 2, 2026 | King-Jones Heidy | See Remarks | Sell | 400 | 90.00 | 36,000 |
| Sep 2, 2026 | King-Jones Heidy | See Remarks | Other | 400 | 14.50 | 5,800 |
| Sep 2, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 18,232 | 89.35 | 1,629,029 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Sell | 400 | 89.38 | 35,752 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Sell | 6,206 | 88.17 | 547,183 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Sell | 16,548 | 87.20 | 1,442,986 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Sell | 4,845 | 86.40 | 418,608 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Other | 27,999 | 14.50 | 405,986 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 200 | 89.04 | 17,808 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 2,016 | 88.03 | 177,468 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 4,384 | 87.11 | 381,890 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 900 | 86.25 | 77,625 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Other | 7,500 | 14.50 | 108,750 |
| Sep 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 400 | 89.07 | 35,628 |
| Sep 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 3,700 | 88.06 | 325,822 |
| Sep 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 8,400 | 87.15 | 732,060 |
| Sep 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 2,500 | 86.36 | 215,900 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | Sell | 10,000 | 104.68 | 1,046,800 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | Sell | 8,000 | 104.38 | 835,040 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | Sell | 5,000 | 104.47 | 522,350 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | Other | 5,000 | 10.39 | 51,950 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 100 | 97.10 | 9,710 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 2,300 | 96.30 | 221,490 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 5,100 | 95.21 | 485,571 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | Other | 7,500 | 14.50 | 108,750 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 16 | 97.46 | 1,559 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 1,392 | 96.82 | 134,773 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 5,635 | 95.93 | 540,566 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 7,157 | 95.10 | 680,631 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 800 | 93.97 | 75,176 |
Reportable transactions by officers and major shareholders from SEC Form 4 filings. "Other" includes things like stock grants and option exercises without a buy/sell character. View all insider transactions →
Data as of: October 30, 2026 · Source: fundamental data & SEC filings (annual and quarterly reports, 10-K/10-Q)
Note: pure fact-based analysis, not investment advice and not a solicitation to buy or sell. All figures without guarantee.