Spyre Therapeutics Inc.
Ownership
Ownership Structure
Who owns Spyre Therapeutics Inc. (SYRE)? This page shows the largest institutions and funds, the ownership structure and the latest insider transactions. 93.2% of the shares are freely tradable; institutional investors hold 93.2%.
Largest Shareholders
Institutions
| Name | Stake (%) | Shares | Change (%) | Date |
|---|---|---|---|---|
| FMR Inc | 13.36 | 11,781,024 | +1.2 | 03/31/2026 |
| BlackRock Inc | 6.26 | 5,521,221 | +0.0 | 03/31/2026 |
| Perceptive Advisors LLC | 4.90 | 4,319,496 | +14.2 | 06/30/2026 |
| RTW INVESTMENTS, LLC | 4.73 | 4,171,996 | +0.0 | 03/31/2026 |
| Fairmount Funds Management LLC | 4.56 | 4,018,101 | +0.0 | 03/31/2026 |
| Paradigm Biocapital Advisors LP | 4.36 | 3,840,778 | +96.2 | 06/30/2026 |
| VR Adviser, LLC | 4.18 | 3,685,448 | +0.0 | 03/31/2026 |
| Vanguard Capital Management, LLC | 3.47 | 3,057,401 | +0.0 | 03/31/2026 |
| Driehaus Capital Management LLC | 3.17 | 2,790,785 | -3.2 | 03/31/2026 |
Funds
| Name | Stake (%) | Shares | Change (%) | Date |
|---|---|---|---|---|
| Fidelity Growth Compy Commingled Pl S | 4.18 | 3,688,751 | +0.2 | 07/31/2026 |
Largest reported positions according to regulatory filings; stake as a percentage of shares outstanding, change versus the previous filing. Source: fundamentals data.
Insider holdings
| Person | Role | Shares | Value | As of | Type |
|---|---|---|---|---|---|
| Turtle Cameron | Chief Executive Officer | 552,540 | 51,220,458 $ | Sep 1, 2026 | direct |
| Burrows Scott L | Chief Financial Officer | 79,762 | 7,393,937 $ | Sep 2, 2026 | direct |
| Albers Jeffrey W. | Director | 9,360 | 867,672 $ | Aug 7, 2026 | both |
| King-Jones Heidy | See Remarks | 2,845 | 263,732 $ | Sep 2, 2026 | direct |
Holdings as of each person's most recent SEC Form 4 filing — excluding options and RSUs, which are not shares yet. Holdings may have changed between two filings.
Insiders
Insider Transactions
| Date | Person | Role | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Sep 2, 2026 | King-Jones Heidy | See Remarks | Sell | 400 | 90.00 | 36,000 |
| Sep 2, 2026 | King-Jones Heidy | See Remarks | Other | 400 | 14.50 | 5,800 |
| Sep 2, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 18,232 | 89.35 | 1,629,029 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Sell | 400 | 89.38 | 35,752 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Sell | 6,206 | 88.17 | 547,183 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Sell | 16,548 | 87.20 | 1,442,986 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Sell | 4,845 | 86.40 | 418,608 |
| Sep 1, 2026 | King-Jones Heidy | See Remarks | Other | 27,999 | 14.50 | 405,986 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 200 | 89.04 | 17,808 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 2,016 | 88.03 | 177,468 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 4,384 | 87.11 | 381,890 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 900 | 86.25 | 77,625 |
| Sep 1, 2026 | Burrows Scott L | Chief Financial Officer | Other | 7,500 | 14.50 | 108,750 |
| Sep 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 400 | 89.07 | 35,628 |
| Sep 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 3,700 | 88.06 | 325,822 |
| Sep 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 8,400 | 87.15 | 732,060 |
| Sep 1, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 2,500 | 86.36 | 215,900 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | Sell | 10,000 | 104.68 | 1,046,800 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | Sell | 8,000 | 104.38 | 835,040 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | Sell | 5,000 | 104.47 | 522,350 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | Other | 5,000 | 10.39 | 51,950 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 100 | 97.10 | 9,710 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 2,300 | 96.30 | 221,490 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | Sell | 5,100 | 95.21 | 485,571 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | Other | 7,500 | 14.50 | 108,750 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 16 | 97.46 | 1,559 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 1,392 | 96.82 | 134,773 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 5,635 | 95.93 | 540,566 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 7,157 | 95.10 | 680,631 |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | Sell | 800 | 93.97 | 75,176 |
Reportable transactions by officers and major shareholders from SEC Form 4 filings. "Other" includes things like stock grants and option exercises without a buy/sell character. View all insider transactions →
Data as of: September 17, 2026 · Source: fundamental data & SEC filings (annual and quarterly reports, 10-K/10-Q)
Note: pure fact-based analysis, not investment advice and not a solicitation to buy or sell. All figures without guarantee.