IONS
Ionis Pharmaceuticals Inc
43.30$
-1.9%
vs. previous close
Closing price · As of: Oct 8, 2026
Statements
Ratios
Valuation ratios (P/E, P/S, EV/EBITDA and the other multiples) are based on the closing price at the end of each period, not on the current price. Margins and returns are shown in percent, multiples without a unit, per-share figures in the reporting currency, net debt in millions.
Tick rows to compare them in a chart (up to 4)
| Line item | Q3 16 | Q4 16 | Q1 17 | Q2 17 | Q3 17 | Q4 17 | Q1 18 | Q2 18 | Q3 18 | Q4 18 | Q1 19 | Q2 19 | Q3 19 | Q4 19 | Q1 20 | Q2 20 | Q3 20 | Q4 20 | Q1 21 | Q2 21 | Q3 21 | Q4 21 | Q1 22 | Q2 22 | Q3 22 | Q4 22 | Q1 23 | Q2 23 | Q3 23 | Q4 23 | Q1 24 | Q2 24 | Q3 24 | Q4 24 | Q1 25 | Q2 25 | Q3 25 | Q4 25 | Q1 26 | Q2 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Valuation | ||||||||||||||||||||||||||||||||||||||||
| – | – | – | 161.4 | 216.4 | 1,061.1 | – | – | – | 29.6 | 32.0 | 22.6 | 20.0 | 31.4 | 38.8 | 56.6 | 70.1 | – | – | – | – | – | – | – | 857.0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| 19.0 | 17.1 | 11.8 | 12.6 | 12.4 | 12.3 | 10.1 | 9.7 | 12.2 | 13.5 | 15.3 | 11.3 | 10.5 | 8.2 | 6.9 | 8.7 | 7.1 | 10.8 | 9.0 | 8.2 | 7.2 | 6.0 | 6.2 | 6.2 | 7.2 | 9.1 | 8.8 | 9.3 | 10.6 | 12.6 | 11.1 | 11.4 | 10.0 | 7.8 | 6.7 | 7.6 | 10.9 | 13.6 | 11.7 | 15.0 | |
| 32.3 | 59.5 | 24.9 | 29.3 | 20.5 | 19.3 | 18.3 | 7.7 | 10.0 | 7.7 | 9.5 | 7.1 | 6.4 | 6.3 | 4.8 | 6.0 | 4.8 | 9.4 | 9.3 | 9.7 | 8.9 | 6.3 | 7.4 | 8.4 | 10.6 | 9.4 | 10.5 | 13.7 | 20.6 | 24.8 | 21.3 | 26.4 | 9.0 | 9.4 | 10.1 | 11.4 | 17.0 | 26.2 | 25.2 | 29.8 | |
| 20.3 | 16.6 | 12.7 | 12.0 | 13.3 | 11.5 | 9.3 | 9.4 | 12.5 | 11.1 | 15.6 | 9.3 | 11.0 | 6.7 | 7.2 | 9.0 | 7.3 | 9.4 | 9.7 | 9.3 | 8.1 | 4.9 | 12.0 | 12.6 | 8.2 | 10.7 | 10.4 | 10.7 | 12.0 | 14.2 | 12.7 | 13.1 | 11.5 | 9.3 | 8.1 | 8.6 | 11.8 | 15.1 | 13.2 | 16.4 | |
| – | – | 143.0 | 63.5 | 82.2 | 145.7 | 241.5 | – | – | – | 101.7 | 47.2 | 49.6 | 18.3 | 30.4 | 42.7 | 44.0 | – | – | – | – | – | 631.4 | – | 232.4 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| – | – | 70.2 | 59.9 | 66.3 | 46.8 | 197.9 | 10.2 | 14.7 | 13.9 | 16.9 | 58.7 | 55.8 | 29.9 | 35.0 | 49.7 | 38.4 | – | – | – | – | 377.1 | 148.1 | 64.2 | 56.8 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| -3.0% | -2.1% | 1.4% | 1.7% | 1.5% | 2.1% | 0.5% | 9.8% | 6.8% | 7.2% | 5.9% | 1.7% | 1.8% | 3.3% | 2.9% | 2.0% | 2.6% | -0.1% | -0.7% | -1.0% | -2.0% | 0.3% | 0.7% | 1.6% | 1.8% | -5.5% | -7.9% | -8.4% | -8.8% | -7.1% | -8.5% | -8.1% | -9.7% | -10.2% | -11.9% | -4.1% | -2.9% | -2.5% | -7.8% | -4.3% | |
| Margins | ||||||||||||||||||||||||||||||||||||||||
| -44.8% | 0.7% | 18.7% | 29.5% | 31.4% | 27.8% | 46.6% | 62.3% | 77.9% | 80.8% | 84.5% | 85.3% | 85.5% | 99.6% | 99.4% | 99.2% | 99.0% | 98.4% | 98.3% | 98.3% | 98.2% | 98.7% | 98.5% | 98.3% | 98.6% | 97.6% | 98.0% | 98.6% | 98.4% | 98.6% | 98.4% | 98.2% | 98.4% | 98.4% | 98.5% | 98.9% | 98.8% | 98.3% | 98.3% | 98.2% | |
| -63.2% | -13.4% | 6.5% | 16.7% | 15.5% | 6.9% | 2.3% | -8.0% | -12.7% | -10.2% | 8.4% | 11.9% | 14.1% | 32.6% | 19.1% | 16.0% | 11.9% | -23.6% | -28.7% | -32.6% | -41.4% | -3.7% | 0.5% | -1.0% | 2.1% | -69.8% | -81.1% | -74.8% | -90.3% | -85.3% | -93.2% | -83.6% | -85.9% | -67.4% | -65.9% | -28.2% | -28.8% | -40.5% | -33.3% | -68.1% | |
| -77.3% | -25.0% | -3.4% | 7.8% | 5.7% | 1.2% | -0.8% | -7.5% | -7.5% | 45.6% | 47.8% | 50.0% | 52.3% | 26.2% | 17.7% | 15.5% | 10.2% | -59.0% | -67.9% | -77.9% | -89.8% | -3.5% | -0.5% | -3.3% | 0.8% | -45.9% | -57.1% | -49.0% | -66.6% | -85.8% | -90.7% | -82.1% | -82.3% | -64.4% | -63.9% | -28.4% | -26.5% | -40.4% | -30.9% | -64.6% | |
| -56.5% | -35.7% | 16.8% | 21.1% | 18.8% | 26.3% | 5.1% | 95.0% | 83.3% | 97.6% | 90.2% | 19.2% | 18.7% | 27.6% | 19.7% | 17.6% | 18.5% | -0.7% | -6.4% | -8.6% | -14.5% | 1.6% | 4.2% | 9.6% | 12.6% | -50.1% | -70.3% | -78.2% | -93.3% | -90.0% | -93.4% | -92.7% | -96.2% | -79.6% | -79.4% | -30.9% | -31.3% | -33.9% | -91.8% | -64.0% | |
| Returns | ||||||||||||||||||||||||||||||||||||||||
| -131.7% | -86.9% | -7.3% | 18.1% | 9.5% | 1.8% | -1.4% | -6.0% | -6.1% | 26.1% | 29.8% | 31.4% | 32.2% | 20.0% | 12.5% | 10.6% | 6.8% | -51.0% | -70.6% | -91.9% | -111.9% | -3.7% | -0.5% | -4.5% | 1.2% | -47.1% | -67.6% | -72.2% | -129.8% | -168.6% | -174.8% | -189.3% | -74.3% | -77.1% | -96.3% | -42.5% | -41.5% | -77.9% | -66.5% | -128.4% | |
| -21.8% | -9.5% | -1.4% | 3.6% | 2.3% | 0.5% | -0.3% | -1.9% | -1.9% | 10.3% | 12.7% | 13.9% | 14.8% | 9.1% | 5.5% | 4.7% | 3.1% | -18.0% | -21.4% | -21.4% | -24.6% | -1.1% | -0.2% | -1.1% | 0.3% | -10.6% | -11.4% | -10.4% | -14.0% | -18.1% | -18.8% | -18.6% | -16.0% | -15.1% | -16.3% | -9.0% | -8.5% | -10.8% | -9.5% | -18.9% | |
| Balance Sheet & Debt | ||||||||||||||||||||||||||||||||||||||||
| 324 | -163 | 394 | -318 | 425 | -428 | -434 | -194 | 154 | -1,442 | 276 | -1,601 | 410 | -1,728 | 298 | 264 | 172 | -1,083 | 496 | 737 | 649 | -890 | 4,886 | 5,433 | 914 | 914 | 886 | 899 | 889 | 925 | 926 | 983 | 944 | 1,013 | 999 | 958 | 888 | 1,428 | 1,608 | 1,243 | |
| – | – | 10.4 | -3.4 | 5.2 | -10.5 | -20.6 | – | – | – | 2.4 | -10.2 | 2.3 | -4.2 | 1.3 | 1.3 | 1.1 | – | – | – | – | – | 304.7 | – | 29.6 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| 16.6% | 10.9% | 18.6% | 19.8% | 24.6% | 25.0% | 23.2% | 31.0% | 31.6% | 39.3% | 42.6% | 44.1% | 46.2% | 45.5% | 44.0% | 44.7% | 44.7% | 35.3% | 30.3% | 23.3% | 22.0% | 29.6% | 28.2% | 25.4% | 24.5% | 22.6% | 16.9% | 14.4% | 10.8% | 10.7% | 10.7% | 9.8% | 21.5% | 19.6% | 16.9% | 21.2% | 20.4% | 13.9% | 14.2% | 14.7% | |
| 2.9 | 5.0 | 2.5 | 2.5 | 1.9 | 1.8 | 2.0 | 0.9 | 0.9 | 0.6 | 0.5 | 0.5 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | 1.0 | 1.3 | 2.2 | 2.4 | 1.6 | 7.6 | 9.5 | 2.1 | 2.1 | 2.5 | 3.1 | 3.9 | 4.3 | 4.3 | 4.8 | 1.9 | 2.1 | 2.7 | 2.0 | 2.0 | 3.7 | 3.6 | 3.6 | |
| Per Share | ||||||||||||||||||||||||||||||||||||||||
| -1.49 | -0.70 | -0.12 | 0.32 | 0.23 | 0.05 | -0.03 | -0.32 | -0.32 | 1.83 | 2.54 | 2.85 | 3.00 | 1.92 | 1.22 | 1.04 | 0.68 | -3.07 | -3.41 | -3.80 | -4.20 | -0.18 | -0.03 | -0.20 | 0.05 | -1.90 | -2.30 | -2.16 | -2.86 | -3.43 | -3.56 | -3.42 | -3.31 | -2.87 | -2.89 | -1.47 | -1.59 | -2.35 | -1.98 | -3.41 | |
| 1.93 | 2.80 | 3.41 | 4.03 | 4.07 | 4.09 | 4.37 | 4.29 | 4.22 | 4.00 | 5.32 | 5.69 | 5.73 | 7.34 | 6.88 | 6.75 | 6.68 | 5.21 | 5.03 | 4.88 | 4.68 | 5.07 | 5.94 | 5.99 | 6.17 | 4.14 | 4.04 | 4.41 | 4.29 | 4.00 | 3.93 | 4.17 | 4.02 | 4.46 | 4.52 | 5.18 | 6.01 | 5.82 | 6.42 | 5.28 | |
| 1.13 | 0.80 | 1.61 | 1.74 | 2.48 | 2.61 | 2.40 | 5.41 | 5.17 | 6.99 | 8.53 | 9.05 | 9.32 | 9.61 | 9.76 | 9.88 | 9.90 | 6.02 | 4.83 | 4.13 | 3.76 | 4.83 | 5.01 | 4.41 | 4.19 | 4.03 | 3.41 | 2.99 | 2.20 | 2.04 | 2.04 | 1.81 | 4.46 | 3.72 | 3.00 | 3.46 | 3.84 | 3.02 | 2.98 | 2.66 | |
| -1.09 | -1.00 | 0.57 | 0.85 | 0.77 | 1.07 | 0.22 | 4.08 | 3.52 | 3.91 | 4.79 | 1.10 | 1.07 | 2.02 | 1.35 | 1.19 | 1.24 | -0.04 | -0.32 | -0.42 | -0.68 | 0.08 | 0.25 | 0.58 | 0.78 | -2.07 | -2.84 | -3.44 | -4.00 | -3.60 | -3.67 | -3.86 | -3.87 | -3.55 | -3.59 | -1.60 | -1.88 | -1.98 | -5.89 | -3.38 | |
Showing the most recent 40 periods — older statements are on file for this stock.
Data as of: October 8, 2026 · Source: fundamental data & SEC filings (annual and quarterly reports, 10-K/10-Q)
Note: pure fact-based analysis, not investment advice and not a solicitation to buy or sell. All figures without guarantee.